What If? intertwines the stories of four people from dissimilar backgrounds. Tilottima and Hemant's honeymoon is cut short because Hemant has suddenly to return to his job in the US. Tilottima will do what it takes to join her husband. Salim Rajabali, besotted by a much older, woman, is involuntarily involved in a killing, and discovers she has been cheating on him. Before he can recover, his mother forces him to flee the country. Rahul Bhide, a brilliant but poor student, secures admission to a university abroad but knows that his father cannot afford the fees. But overnight, all his problems are somehow resolved and he flies out to a brighter future. And Rajubhai Patel, a small-time organiser of foreign shows, finds himself accompanying a wide-eyed, innocent girl on her first trip abroad.
Four people with distinct hopes and motives whom fate has randomly selected to play their assigned roles in one of the most terrible events of recent times. One fell stroke will alter destinies - and four lives will change forever.